医药卫生—临床医学

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Choroid plexus tumor necrosis factor receptor 1:a new neuroinflammatory piece of the complex Alzheimer’s disease puzzle
《中国神经再生研究:英文版》2019年第7期1144-1147,共4页Sophie Steeland Roosmarijn E.Vandenbroucke 
the Research Foundation Flanders(FWO);The Foundation for Alzheimer’s Research Belgium(SAO-FRA);European Union Cost action MouseAge(BM1402);the Baillet Latour Fund(all to SS and REV).
Due to the aging of the population and despite the enormous scientific effort,Alzheimer’s disease remains one of the biggest medical and pharmaceutical challenges in current medicine.Novel insights highlight the impo...
关键词:tumor necrosis factor NEUROINFLAMMATION blood-cerebrospinal fluid barrier PRECLINICAL research drug development NEURODEGENERATION cognitive decline mouse models TNFR 
Amelioration of Alzheimer’s disease pathology and cognitive deficits by immunomodulatory agents in animal models of Alzheimer’s disease
《中国神经再生研究:英文版》2019年第7期1158-1176,共19页Bridget Martinez Philip V.Peplow 
The most common age-related neurodegenerative disease is Alzheimer’s disease(AD)characterized by aggregated amyloid-β(Aβ)peptides in extracellular plaques and aggregated hyperphosphorylated tau protein in intraneur...
关键词:Alzheimer’s disease NEUROPATHOLOGY cognitive deficits behavioral deficits IMMUNOMODULATORY agents animal models amyloid deposits GLIOSIS 
Decreased numbers of circulating endothelial progenitor cells are associated with hyperglycemia in patients with traumatic brain injury
《中国神经再生研究:英文版》2019年第6期984-990,共7页Hui-Jie Wei Li Liu Fang-Lian Chen Dong Wang Liang Wang Zeng-Guang Wang Rong-Cai Jiang Jing-Fei Dong Jie-Li Chen Jian-Ning Zhang 
the National Natural Science Foundation of China,No.30772229(to JNZ),No.81200907(to HJW);the Natural Science Foundation of Tianjin of China,No.12JCQNJC06800(to HJW);the Science and Technology Projects in Key Areas of Traditional Chinese Medicine of Tianjin of China,No.2018001(to ZGW);the Scientific Research Program Project of Tianjin Education Commission of China,No.2018ZD03(to ZGW).
Hyperglycemia reduces the number of circulating endothelial progenitor cells,accelerates their senescence and impairs their function.However,the relationship between blood glucose levels and endothelial progenitor cel...
关键词:nerve REGENERATION endothelial progenitor cells VASCULAR repair VASCULAR remodeling angiogenesis NEOVASCULARIZATION blood glucose HYPERGLYCEMIA traumatic BRAIN injury MOBILIZATION suppression senescence alternative therapy BRAIN damage neural REGENERATION 
Neurological functional evaluation based on accurate motions in big animals with traumatic brain injury
《中国神经再生研究:英文版》2019年第6期991-996,共6页Ji-Peng Jiang Xue-Gang Niu Chen Dai Ke Ma Hui-You Xu Shi-Xiang Cheng Zhi-Wen Zhang Feng Duan Xu Zhu Yu-Ting Wang Xu-Yi Chen Sai Zhang 
the National Natural Science Foundation of China,No.11672332,11102235 and 31200809(all to XYC);the National Key Research and Development Plan of China,No.2016YFC1101500(to SZ);the Science and Technology Program of Tianjin,China,No.17YFZCSY00620 and 16ZXHLSY00120(both to XYC).
An accurate and effective neurological evaluation is indispensable in the treatment and rehabilitation of traumatic brain injury.However,most of the existing evaluation methods in basic research and clinical practice ...
关键词:nerve REGENERATION evaluation method NEUROLOGICAL deficiency TRAUMATIC brain injury motion capture ELECTROMYOGRAM ground reaction force neural REGENERATION 
Effect of lentiviral vector-mediated overexpression of hypoxia-inducible factor 1 alpha delivered by pluronic F-127 hydrogel on brachial plexus avulsion in rats
《中国神经再生研究:英文版》2019年第6期1069-1078,共10页Tao Wang Li-Ni Zeng Zhe Zhu Yu-Hui Wang Lu Ding Wei-Bin Luo Xiao-Min Zhang Zhi-Wei He Hong-Fu Wu 
the National Natural Science Foundation of China,No.81371366(to HFW);the Natural Science Foundation of Guangdong Province of China,No.2015A030313515(to HFW);the Dongguan International Science and Technology Cooperation Project,No.2013508152010(to HFW);the Key Project of Social Development of Dongguan of China,No.20185071521640(to HFW).
Brachial plexus avulsion often results in massive motor neuron death and severe functional deficits of target muscles.However,no satisfactory treatment is currently available.Hypoxia-inducible factor 1αis a critical ...
关键词:NERVE REGENERATION peripheral NERVE injury brachial plexus AVULSION HYPOXIA ischemia hypoxia-inducible factor 1αoverexpression PLURONIC F-127 motor neurons axonal REGENERATION angiogenesis neural REGENERATION 
Neural-like cells from adipose-derived stem cells for cavernous nerve injury in rats
《中国神经再生研究:英文版》2019年第6期1085-1090,共6页Cheng-Cheng Ying1 Mei Yang Yong Wang Yong-Lian Guo Wan-Li Hu Xin-Min Zheng 
the Fundamental Research Funds for the Central Hospital of Wuhan of China,No.YB16A01(to CCY);the Natural Science Foundation of Hubei Province of China,No.2017CFB176(to CCY).
Although the remaining nerve tissue can regenerate and partly restore erectile function when the cavernous nerve is compressed/severed and function lost,the limited regenerative ability of these nerve tissues often fa...
关键词:NERVE REGENERATION adipose-derived NEURAL stem CELLS corpus cavernosum CAVERNOUS NERVE erectile dysfunction radical prostatectomy neurons cell differentiation NEURAL REGENERATION 
Mechanism of persistent hyperalgesia in neuropathic pain caused by chronic constriction injury
《中国神经再生研究:英文版》2019年第6期1091-1098,共8页Qin-Yi Chen Chao-Yang Tan Yang Wang Ke-Tao Ma Li Li Jun-Qiang Si 
the National Natural Science Foundation of China,No.30160026(to JQS);the High Level Talent Research Project of Shihezi University of China,No.RCSX201705(to YW).
Transmembrane member 16A(TMEM16A)is involved in many physiological functions,such as epithelial secretion,sensory conduction,nociception,control of neuronal excitability,and regulation of smooth muscle contraction,and...
关键词:NERVE REGENERATION TMEM16A calcium-activated chloride channels T16Ainh-A01 NEUROPATHIC pain dorsal root ganglia HYPERALGESIA action potential rheobase chronic CONSTRICTION INJURY peripheral NERVE INJURY neural REGENERATION 
Comparative study of microarray and experimental data on Schwann cells in peripheral nerve degeneration and regeneration:big data analysis
《中国神经再生研究:英文版》2019年第6期1099-1104,共6页Ulfuara Shefa Junyang Jung 
Basic Science Research Program through the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(2018R1D1A1B07040282;to JJ);a grant from Kyung Hee University in 2018(KHU-20181065;to JJ).
A Schwann cell has regenerative capabilities and is an important cell in the peripheral nervous system.This microarray study is part of a bioinformatics study that focuses mainly on Schwann cells.Microarray data provi...
关键词:Schwann cells big data analysis PERIPHERAL NERVE DEGENERATION PERIPHERAL NERVE REGENERATION MICROARRAY matched GENES promising GENES gene ranking 
The paradigm of protein acetylation in Parkinson’s disease
《中国神经再生研究:英文版》2019年第6期975-976,共2页Sokhna M.S.Yakhine-Diop Guadalupe Martínez-Chacón Elisabet Uribe-Carretero Mireia Niso-Santano Rosa A.González-Polo JoséM.Fuentes 
Yakhine-Diop SMS was supported by Isabel Gemio Foundation;Uribe-Carretero E was supported by a FPU predoctoral fellowship FPU16/00684 from Ministerio de Educacion,Cultura y Deporte,Spain.Niso-Santano M was funded by“Ramon y Cajal Program(RYC-2016-20883)Spain;Gonzalez-Polo RA was supported by a“Contrato destinado a la retencion y atraccion del talento investigador,TA13009”from Junta de Extremadura;JM.F.received research support from the Instituto de Salud Carlos III,CIBERNED(CB06/05/004);Instituto de Salud Carlos III,FIS,(PI15/00034);“Fondo Europeo de Desarrollo Regional”(FEDER)from the European Union.
Acetylation is a post-translational modification that is regulated by two antagonistic enzymes,histone acetyltransferases(HATs)and histone deacetylases(HDACs).HATs transfer the acetyl group from acetyl-CoA to lysine r...
关键词:PARKINSON PROTEIN Α-SYNUCLEIN HDACS cells gene is 
Acute histopathological responses and long-term behavioral outcomes in mice with graded controlled cortical impact injury
《中国神经再生研究:英文版》2019年第6期997-1003,共7页Si-Yi Xu Min Liu Yang Gao Yang Cao Jin-Gang Bao Ying-Ying Lin Yong Wang Qi-Zhong Luo Ji-Yao Jiang Chun-Long Zhong 
the National Natural Science Foundation of China,No.81771332,81571184,81070990(all to CLZ);the Shanghai Key Medical Discipline for Critical Care Medicine of China,No.2017zz02017(to CLZ);the Key Discipline Construction Project of Pudong Health Bureau of Shanghai of China,No.PWZxk2017-23,PWYgf2018-05(both to CLZ);the Outstanding Leaders Training Program of Pudong Health Bureau of Shanghai of China,No.PWR12018-07(to CLZ).
While animal models of controlled cortical impact often display short-term motor dysfunction after injury,histological examinations do not show severe cortical damage.Thus,this model requires further improvement.Mice ...
关键词:nerve REGENERATION traumatic brain INJURY controlled cortical impact HISTOPATHOLOGY BEHAVIORAL MANIFESTATIONS neural REGENERATION 
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