IL-1β、MMP-8和胎儿胸腺等预测胎膜早破合并绒毛膜羊膜炎的研究进展  

Advances in the Prediction of Premature Rupture of Membranes with Chorioamnionitis by IL-1β, MMP-8 and Fetal Thymus

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作  者:周丽[1] 王永红(审校者)[1] ZHOU Li;WANG Yong-hong.(Department of Obstetrics and Gynecology, The Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区:[1]山西医科大学第二医院妇产科,太原030001

出  处:《国际妇产科学杂志》2019年第1期44-47,共4页JOURNAL OF INTERNATIONAL OBSTETRICS AND GYNECOLOGY

基  金:山西省重点研发计划(指南)项目(201603D321038);山西医科大学校级博士启动基金项目(BS201713).

摘  要:胎膜早破(premature rupture of membrane,PROM)常发生于妊娠中晚期。胎膜破裂后,阴道内的致病微生物可沿胎膜破口进入羊膜腔,可诱发绒毛膜羊膜炎(chorioamnionitis,CA),导致胎儿窘迫和新生儿感染败血症等严重并发症的发生,是临床围生儿病死率升高的重要原因。大多数患者在胎膜早破后短期内没有临床症状,但早期预警并给予相应处理可明显降低围生儿患病率和死亡率,如孕晚期B型溶血性链球菌筛查及相应的治疗。近年研究发现,除传统的实验室预测指标如白细胞介素6(IL-6)外,IL-1β、基质金属蛋白酶8(MMP-8)和胎儿胸腺的超声测量等对CA具有一定的预测价值。综述近年来PROM并发CA早期预测指标的研究进展。Premature rupture of membrane (PROM) often occurs in the second and third trimester. After the membrane rupture, the pathogenic microorganisms in the vagina can induce chorioamnionitis (CA) when enter the amniotic cavity via the broken membrane, resulting in serious complications such as fetal distress or neonatal infection sepsis which associated with high mortality in perinatal children. Most patients are absent of clinical symptoms in the short-term after PROM, and early warning and treatments can significantly reduce the prevalence and mortality of perinatal infants, such as the screening and treatments of type B hemolytic streptococcus in the third trimester. Recently, studies indicated that in addition to traditional laboratory predictions such as interleukin-6 (IL-6), IL-1β, matrix metalloproteinase-8 (MMP-8) and ultrasound measurements of fetal thymus had certain prediction value for CA. Therefore, this review summarized the markers to predict CA in early stage in women complicated with CA in recent years.

关 键 词:胎膜早破 绒毛膜羊膜炎 白细胞介素1Β 基质金属蛋白酶8 胎儿胸腺 

分 类 号:R135.1[医药卫生—劳动卫生;医药卫生—公共卫生与预防医学]

 

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