邻苯二甲酸二(2-乙基己基)酯(DEHP)对大型溞的生殖毒性及跨代效应  

Reproductive toxicity and transgenerational effects of di(2-ethylhexyl) phthalate (DEHP) on water fleas Daphnia magna

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作  者:魏杰[1] 申晨晨 赵文[1] 王媛[1] 班艳丽[1] 申祺 王天艺 谢玺[2] WEI Jie;SHEN Chen-chen;ZHAO Wen;WANG Yuan;BAN Yan-li;SHEN Qi;WANG Tian-yi;XIE Xi(Key Laboratory of Hydrobiology in Liaoning Province, Dalian Ocean University, Dalian 116023, China;Liaoning Open Laboratory of Applied Marine Biology, Liaoning Ocean and Fisheries Science Research Institute, Dalian 116023, China)

机构地区:[1]大连海洋大学辽宁省水生生物学重点实验室,辽宁大连116023 [2]辽宁省海洋水产科学研究院辽宁省应用海洋生物技术开放实验室,辽宁大连116023

出  处:《大连海洋大学学报》2019年第1期1-6,共6页Journal of Dalian Fisheries University

基  金:国家自然科学基金资助项目(41501535,40806047);国家科技基础专项(2014FY210700);辽宁省博士科研启动基金资助项目(201601387).

摘  要:为研究邻苯二甲酸二2-乙基己基)酯(DEHP)对大型溞Daphniamagna的急性毒性效应和多个世代(P、F1和F3代)生殖与种群增长影响,采用实验生态学方法,通过急性和慢性毒性试验进行了相关研究。结果表明:急性毒性试验中,DEHP对大型溞24h、48h的LC50分别为0.820、0.569mg/L,安全浓度为0.082mg/L,属于高毒物质;慢性毒性试验中,浓度为0.03~0.07mg/L的DEHP对大型溞的生殖和种群增长具有一定毒性作用,浓度为0.06~0.07mg/L的DEHP对大型溞P代的总生殖量、平均生殖量、第一胎生殖量、产幼间隔和种群增长有明显促进作用,对大型溞F1代影响不明显,而对F3代总生殖量、平均生殖量和种群增长具有一定抑制作用。本研究结果可为邻苯二甲酸酯的安全性评价提供科学依据。The acute and chronic toxicities of di(2-ethylhexyl)phthalate (DEHP) to water fleas Daphnia magna were investigated in DEHP concentration of 0 (as control group, CK ), 0.4, 0.6, 0.8, 1.0, 1.2 and 1.4 mg/L in acute toxicity and of 0, 0.03, 0.04, 0.05, 0.06, and 0.07 mg/L in chronic toxicity (acetone solvent as control group, CK-S) at water temperature of (23±1)℃ by experimental ecology methods to evaluate the effects of DEHP on fecundity and population growth of three generations (P, F1 and F3) of the water fleas. In acute toxicity test, the LC 50 of DEHP was found to be 0.820 mg/L in 24 h and 0.569 mg/L in 48 h with safety concentration of 0.082 mg/L, suggesting that DEHP was a highly toxic chemical compound. The chronic toxicity test revealed that somewhat toxic effects on distinct generations of offspring were observed at DEHP concentration ranging from 0.03 to 0.07 mg/L. The positive improvement of total number of neonates, average number of neonates per brood, first breeding interval, and average interval between broods and intrinsic population growth of the P generation was found at 0.06- 0.07 mg/L of DEHP, without distinct effect in the F1 generation. In the F3 generation, however, the total number of neonates, average number of neonates per brood and intrinsic population growth were to some extent inhibited by DEHP. The findings provide basic information for safety assessment of phthalates.

关 键 词:邻苯二甲酸二(2-乙基己基)酯 大型溞 生殖毒性 跨代效应 

分 类 号:Q143[生物学—生态学;生物学—普通生物学]

 

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