老年住院患者潜在不适当用药情况及影响因素  

Prevalence and Risk Factors of Potentially Inappropriate Medication in Elderly Inpatients According to the Chinese PIM List

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作  者:徐鹏[1] 张国柱 XU Peng;ZHANG Guozhu(Department of Pharmacy,Hefei Third Clinical College of Anhui Medical University (the Third People’s Hospital of Hefei City),Hefei 230022,China)

机构地区:[1]安徽医科大学合肥第三临床学院(合肥市第三人民医院)药学部,合肥230022

出  处:《医药导报》2019年第3期388-391,共4页Herald of Medicine

摘  要:目的 使用中国老年人潜在不适当用药(PIM)目录和2015年版Beers标准评价住院老年患者PIM现状。方法 收集2017年1—6月在合肥市第三人民医院内科住院、年龄≥65岁患者的病历资料,记录患病种数、住院天数、用药种数等信息,依据中国老年人PIM目录(包括72种药物)和2015年版Beers标准(与年龄相关的PIM,包括62种药物)分析患者PIM情况,采用Logistic回归方法分析PIM影响因素。结果 纳入患者431例,男236例,女195例;年龄650x0E?Symbol~A@0x0F97岁,平均(76.1±7.3)岁;65~<80岁组284例(65.9%),≥80岁组147例(34.1%)。依据中国老年人PIM目录和2015年版Beers标准判断,PIM发生率分别为52.7%(227/431)和24.6%(106/431)(χ2=63.120,P=0.000)。Logistic回归分析显示,依据中国老年人PIM目录判断,PIM主要影响因素为患者年龄[OR=0.700,95%CI(1.292,3.139),P=0.002]和用药种数[OR=1.295,95%CI(2.561,5.208),P=0.000];依据2015年版Beers标准判断,PIM主要影响因素为患病种数[OR=0.334,95%CI(0.989,1.972),P=0.048]和用药种数[OR=0.865,95%CI(1.663,3.392),P=0.000]。结论 该院住院老年患者PIM发生率较高。依据中国老年人PIM目录和Beers标准分析,年龄、用药种数和患病种数会影响PIM发生。Objective To measure the prevalence and risk factors of potentially inappropriate medication (PIM) use among elderly inpatients by using the Chinese PIM list and 2015 Beers criteria. Methods The data of patients ≥65 years of age and hospitalized in Department of Internal Medicine in the Third People’s Hospital of Hefei from January to June in 2017 were collected and the gender, age, department, diseases that patients suffered from, hospitalization days, drug varieties used in one patient, methods of payment were recorded.The situation of PIM was analyzed according to the Chinese PIM list (Chinese list, including 72 drugs) and 2015 Beers criteria (PIM associated with age, including 62 drugs) and the risk factors of PIM use were analyzed by logistic regression. Results A total of 431 patients were enrolled, including 236 males and 195 females.Of the 431 patients, 284(65.9%)patients were 65-<80 years old and 147(34.1%)were ≥80 years old.According to the Chinese list and 2015 Beers criteria, 52.7%(227/431)and 24.6%(106/431) of patients were prescribed one PIM drug(χ 2 =63.120, P =0.000).The results of Logistic regression showed that the main risk factors of PIM use were ages[ OR =0.700,95% CI (1.292,3.139), P = 0.002 ] and varieties of prescribed drugs [ OR =1.295,95% CI (2.561,5.208), P =0.000] by using the Chinese list, and number of diseases that patients suffered from[ OR =0.334,95% CI (0.989,1.972), P =0.048] and varieties of prescribed drugs [ OR = 0.865 ,95% CI (1.663,3.392), P =0.000] by using 2015 Beers criteria. Conclusion According to the Chinese PIM list, the prevalence of PIM use in elderly inpatients in our hospital is higher.The risk factors of PIM use are patients’ age, number of diseases that patient suffered from and varieties of drugs according to the Chinese PIM list and 2015 Beers criteria.

关 键 词:潜在不适当用药 Beers标准 住院患者 老年 患病种数 用药种数 

分 类 号:R969[医药卫生—药理学;医药卫生—药学] R95

 

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