三唑类抗真菌药物肺组织渗透性研究进展  

Research Progress of Permeability of Triazole Antifungal Drugs in Lung Tissue

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作  者:阎鸿焰 黄银 陈诚 秦博 张灵 杨勇 YAN Hongyan;HUANG Yin;CHEN Cheng;QIN Bo;ZHANG Ling;YANG Yong(Personalized Drug Therapy Key Laboratory of Sichuan Province,College of Medicine,University of Electronic Science and Technology of China,Chengdu 611731,China;Department of Pharmacy,Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital,Chengdu 610072,China)

机构地区:[1]电子科技大学医学院,个体化药物治疗四川省重点实验室,成都611731 [2]四川省医学科学院·四川省人民医院药学部,成都610072

出  处:《医药导报》2019年第3期287-293,共7页Herald of Medicine

摘  要:肺部真菌感染患者在使用三唑类抗真菌药物后,肺组织感染/定植部位的药物浓度能够更准确地反映临床疗效。该文总结了肺部真菌感染患者使用三唑类抗真菌药物后肺组织药物浓度的相关研究进展,并综述肺泡上皮衬液中药物浓度测定方法和不同药物渗透特点。In patients with pulmonary fungal infection, the concentration of the drug in the lung tissue infection/colonization site more accurately reflects the clinical efficacy after the use of triazole antifungal drugs.This paper summarized the research progress about triazole antifungal drug concentration in lung tissue of patients with pulmonary fungal infection after administration, and summarized the determination of drug concentration in alveolar epithelial lining fluid and the permeation characteristics of different drugs.

关 键 词:抗真菌药物 三唑类 真菌感染 肺部 肺泡上皮衬液 肺组织浓度 

分 类 号:R978.5[医药卫生—药品;医药卫生—药学] R969

 

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