肾复康片对阳离子化牛血清白蛋白诱发大鼠膜性肾小球肾炎的作用研究  

Effect of Shenfukang Tablet on Membrane Glomerulo-nephritis-induced by Cationic Bovine SerumAlbumin in Rats

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作  者:倪赛宏 袁家升 傅水莲 柳洪峰 何丽明 刘同彦 陈志国 邹丽园 王丹妮 洪铁[1] NI Sai-hong;YUANJia-sheng;FUShui-lian;LIUHong-feng;HE Li-ming;LIUTong-yan;CHENZhi-guo;ZOULi-yuan;WANG Dan-ni;HONG Tie(Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China;Jilinaodong Group Liyuan Pharmaceutical Limited Liability Company,Yanbian 133700,China;College of Chinese Medicine Materials,Jilin Agricultural University,Changchun 130118,China;Department of Pharmacy,China-Japan Union Hospital of Jilin University,Changchun 130033,China)

机构地区:[1]吉林大学药学院药理教研室,长春130021 [2]吉林敖东集团力源制药股份有限公司,吉林延边133700 [3]吉林农业大学中药材学院,长春130118 [4]吉林大学中日联谊医院药剂科,长春130033

出  处:《特产研究》2019年第1期37-41,共5页Special Wild Economic Animal and Plant Research

摘  要:研究肾复康片对大鼠膜性肾小球肾炎的治疗作用。Wistar大鼠73只,随机分为正常对照组、模型对照组、阳性药组、肾复康片高剂量组、中剂量组及低剂量组。除正常对照组外,其他各组大鼠尾静脉注射阳离子化牛血清白蛋白,诱发膜性肾小球肾炎。实验结束时测定大鼠24h尿蛋白量、血肌酐(Scr)、尿素氮(BUN)、总蛋白(TP)、白蛋白(Alb)含量,采用苏木素-伊红染色观察肾脏组织病理状态。结果,与模型对照组相比,肾复康片高剂量组、中剂量组能明显降低24h尿蛋白量、血中Scr含量(P<0.01)、BUN含量(P<0.05),增加TP含量(P<0.05)、Alb含量(P<0.01);病理结果显示,肾复康片能明显改善大鼠肾脏的组织学变化。肾复康片对大鼠膜性肾小球肾炎具有良好的治疗作用。To study the therapeutic effect of Shenfukang tablet on membranous glomerulo-nephritis in rats.73Wistar rats were randomly divided into normal control group, model control group, positive drug group, high dose Shenfukang tablet group, middle dose Shen fukang tablet group and low dose Shenfukang tablet group. The model of membranous glomerulo nephritis was induced by cationic bovine serum albumin injection into the tail vein of rats in other groups except the normal control group. At the end of the experiment, the amount of 24h urine protein,serumcreatinine (Scr), urea nitrogen (BUN), total protein (TP) and albumin (Alb) content were measured in rats. The pathological state of kidney was observed by hematoxyli n-eosin staining.Compared with the model control group,In the high-dose Shenfu- kang table group and middle-dose group , the urine protein content and the level of serumScr (P < 0.01), BUN(P < 0.05) were significantly decreased, and the level of TP (P< 0.05) and Alb (P< 0.01 )were increased. Light microscopic examination of Shenfukang tablets can obviously improve the pathological state of the kidney in rats.Shenfukang tablet has a good therapeutic effect on membranous glomerulonephritis in rats.

关 键 词:膜性肾小球肾炎 阳离子化牛血清白蛋白 肾复康片 尿蛋白 

分 类 号:R961[医药卫生—药理学;医药卫生—药学]

 

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