Regional gray matter abnormality in hepatic myelopathy patients after transjugular intrahepatic portosystemic shunt:a voxel-based morphometry study  

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作  者:Kang Liu Gang Chen Shu-Yao Ren Yuan-Qiang Zhu Tian-Lei Yu Ping Tian Chen Li Yi-Bin Xi Zheng-Yu Wang Jian-Jun Ye Guo-Hong Han Hong Yin 

机构地区:[1]Department of Radiology,Xijing Hospital,Air Force Military Medical University(Fourth Military Medical University),Xi’an,Shaanxi Province,China [2]Department of Radiology,Lanzhou General Hospital,Lanzhou Military Command,Lanzhou,Gansu Province,China [3]Xijing Hospital of Digestive Diseases,Air Force Military Medical University(Fourth Military Medical University),Xi’an,Shaanxi Province,China [4]Life Sciences Research Center,School of Life Sciences and Technology,Xidian University,Xi’an,Shaanxi Province,China

出  处:《中国神经再生研究:英文版》2019年第5期850-857,共8页Neural Regeneration Research

摘  要:Hepatic myelopathy is a complication seen in patients with chronic liver failure with physiologic or iatrogenic portosystemic shunting.The main symptom is progressive lower limb dyskinesia.The role of the brain motor control center in hepatic myelopathy is unknown.This study aimed to investigate the gray matter changes in patients with hepatic myelopathy secondary to transjugular intrahepatic portosystemic shunt and to examine their clinical relevance.This was a cross-sectional study.Twenty-three liver failure patients with hepatic myelopathy(hepatic myelopathy group),23 liver failure patients without hepatic myelopathy(non-hepatic myelopathy group)after transjugular intrahepatic portosystemic shunt,and 23 demographically matched healthy volunteers were enrolled from March 2014 to November 2016 at Xijing Hospital,Air Force Military Medical University(Fourth Military Medical University),China.High-resolution magnetization-prepared rapid gradient-echo brain imaging was acquired.Group differences in regional gray matter were assessed using voxel-based morphometry analysis.The relationship between aberrant gray matter and motor characteristics was investigated.Results demonstrated that compared with the non-hepatic myelopathy group,gray matter volume abnormalities were asymmetric,with decreased volume in the left insula(P=0.003),left thalamus(P=0.029),left superior frontal gyrus(P=0.006),and right middle cingulate cortex(P=0.021),and increased volume in the right caudate nucleus(P=0.017),corrected with open-source software.The volume of the right caudate nucleus in the hepatic myelopathy group negatively correlated with the lower limb clinical rating of the Fugl-Meyer Assessment(r=–0.53,P=0.01).Compared with healthy controls,patients with and without hepatic myelopathy exhibited overall increased gray matter volume in both thalami,and decreased gray matter volume in both putamen,as well as in the globus pallidus,cerebellum,and vermis.The gray matter abnormalities we found predominantly involved motor-related region

关 键 词:portosystemic shunt HEPATIC MYELOPATHY HEPATIC encephalopathy magnetic resonance imaging gray matter lower limb FUGL-MEYER Assessment basal GANGLIA CAUDATE nucleus voxel-based MORPHOMETRY 

分 类 号:R445[医药卫生—影像医学与核医学;医药卫生—诊断学;医药卫生—临床医学] R575

 

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