The paradigm of protein acetylation in Parkinson’s disease  

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作  者:Sokhna M.S.Yakhine-Diop Guadalupe Martínez-Chacón Elisabet Uribe-Carretero Mireia Niso-Santano Rosa A.González-Polo JoséM.Fuentes 

机构地区:[1]Universidad de Extremadura,Departamento de Bioquímica y Biología Molecular y Genética,Facultad de Enfermería y Terapia Ocupacional,Cáceres,Spain [2]Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas(CIBERNED),Madrid,Spain

出  处:《中国神经再生研究:英文版》2019年第6期975-976,共2页Neural Regeneration Research

基  金:Yakhine-Diop SMS was supported by Isabel Gemio Foundation;Uribe-Carretero E was supported by a FPU predoctoral fellowship FPU16/00684 from Ministerio de Educacion,Cultura y Deporte,Spain.Niso-Santano M was funded by“Ramon y Cajal Program(RYC-2016-20883)Spain;Gonzalez-Polo RA was supported by a“Contrato destinado a la retencion y atraccion del talento investigador,TA13009”from Junta de Extremadura;JM.F.received research support from the Instituto de Salud Carlos III,CIBERNED(CB06/05/004);Instituto de Salud Carlos III,FIS,(PI15/00034);“Fondo Europeo de Desarrollo Regional”(FEDER)from the European Union.

摘  要:Acetylation is a post-translational modification that is regulated by two antagonistic enzymes,histone acetyltransferases(HATs)and histone deacetylases(HDACs).HATs transfer the acetyl group from acetyl-CoA to lysine residues of proteins while HDACs remove it(Yakhine-Diop et al.,2018b).The impairment of HAT or HDAC activity elicits changes in the protein acetylation status which disturb several cellular processes,among others,gene expression,autophagy etc.,leading finally to cell death.Both enzymes are associated with Parkinson’s disease(PD)pathogenesis.In dopaminergic cells,neurotoxins provoke apoptotic cell death by increasing histone acetylation levels.While paraquat(Song et al.,2011)and rotenone(Feng et al.,2015)reduce HDAC activity,dieldrin(Song et al.,2010)enhances HAT activity.However in vivo,paraquat-induced upregulation ofα-synuclein triggers histone hypoacetylation.

关 键 词:PARKINSON PROTEIN Α-SYNUCLEIN HDACS cells gene is 

分 类 号:R743.3[医药卫生—神经病学与精神病学;医药卫生—临床医学]

 

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