类风湿关节炎患者血清sCD163测定的临床价值  

Clinical significance of serum sCD163 detection in patients with rheumatoid arthritis

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作  者:颜宇飞 陈奇 李灵筠 姚春艳 朱荣荣 陈燕 秦琴 Yan Yufei;Chen Qi;Li Lingjun;Yao Chunyan;Zhu Rongrong;Chen Yan;Qin Qin(Department of Laboratory Medicine,Kongjiang Hospital,Yangpu District,Shanghai 200093,China)

机构地区:[1]上海市杨浦区控江医院检验科,上海200093 [2]海军军医大学第一附属医院实验诊断科

出  处:《海军医学杂志》2019年第1期51-53,共3页Journal of Navy Medicine

基  金:上海市科委项目(17JC1400900).

摘  要:目的探讨类风湿关节炎(rheumatoid arthritis,RA)患者血清sCD163检测的临床价值。方法采用ELISA法检测了2016年1月至2017年10月在上海市控江医院就诊的88名RA患者和85名健康个体的血清sCD163含量,分析其与患者血清C反应蛋白(CRP)、血沉(ESR)、中性粒细胞淋巴细胞比值(NLR)和DAS-28评分之间的关系。结果RA患者血清sCD163含量[(798±245)ng/ml]较健康个体[(426±240)ng/ml]明显增高,且与患者的CRP、ESR、NLR和DAS-28均呈正相关。结论RA患者的单核巨噬细胞系统处于过度活化状态。sCD163可以用于评价RA患者的疾病活动度。Objective To investigate the clinical significance of serum sCD163 detection in patients with rheumatoid arthritis(RA).Methods Serum sCD163 concentrations in 88 RA patients and 85 healthy controls were detected with ELISA,and the relationship between sCD163 and C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),neutrophil to lymphocyte ratio(NLR),DAS-28 scores were analyzed accordingly.Results Serum sCD163 level in RA patients [(798±245)ng/ml]was significantly increased,as compared with that of the healthy controls [(426±240)ng/ml],ant it was positively correlated with the patient CRP,ESR,NLR and DAS-28.Conclusion Monocyte-macrophage was over-activated in RA patients.sCD163 could be used as a useful tool for disease activity assessment in RA patients.

关 键 词:类风湿关节炎 单核巨噬细胞 sCD163 固有免疫 

分 类 号:R455[医药卫生—运动医学;医药卫生—治疗学;医药卫生—临床医学]

 

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