miRNA-451与非小细胞肺癌患者放疗敏感性的关系  

Relationship between miRNA-451 and radiation sensitivity in patients with non-small cell lung cancer

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作  者:陈志强 亢晓春[2] 陈显钊 王香文 CHEN Zhi-qiang;KANG Xiao-chun;CHEN Xian-zhao;WANG Xiang-wen(People s Hospital of Yilong County,Nanchong,Sichuan 637600,China)

机构地区:[1]仪陇县人民医院,四川仪陇637600 [2]新乡医学院第一附属医院,河南新乡453100 [3]解放军第187中心医院,海南海口571159

出  处:《临床肺科杂志》2019年第3期515-518,共4页Journal of Clinical Pulmonary Medicine

摘  要:目的 分析miRNA-451与非小细胞肺癌(NSCLC)患者放疗敏感性的关系。方法 收集2016年7月至2017年7在我院进行手术切除和术后放疗的NSCLC患者资料,包括性别、年龄、手术切除方式、TNM分期、组织类型和病理分期等,miRNA的测定采用实时定量的PCR法。根据有无局部或远端复发分为放疗敏感组和放疗抵抗组。结果 放疗敏感组和放疗抵抗组各30例,两组在一般临床资料上差别无统计学意义(P >0.05)。放疗敏感组的miRNA-451显著高于放疗抵抗组(3.4±0.9vs2.8±0.8,P=0.008),多因素logistics回归显示miRNA-451高表达与NSCLC患者放疗敏感性相关,受试者工作特征曲线显示miRNA-451诊断NSCLC放疗敏感性的灵敏度为80.25,特异度为59.1%。结论 miRNA-451与NSCLC患者的放疗敏感性有关,可能是一个潜在的治疗靶点。Objective To analyze the relationship between miRNA-451 and the radiosensitivity in patients non-small cell lung cancer(NSCLC).Methods The data of non-small cell lung cancer patients who underwent surgical resection and postoperative radiotherapy in our hospital from July 2016 to 2017 were collected,including sex,age,surgical resection,TNM staging,histological type and pathological stage.It used real-time quantitative PCR to detect miRNA.According to the presence or absence of local or remote recurrence,they were divided into the radiotherapy sensitive group and the radiotherapy resistance group.Results There were 30 cases in the radiotherapy sensitive group and 30 cases in the radiotherapy resistance group.There was no significant differences in general clinical data between the two groups(P >0.05).The miRNA-451 in the radiosensitivity group was significantly higher than that in the radiotherapy resistance group(3.4±0.9 vs 2.8±0.8,P=0.008).Multivariate logistic regression showed that the high expression of miRNA-45 was correlated with the radio-sensitivity of NSCLC patients.The curve showed that the sensitivity of miRNA-451 in the diagnosis of NSCLC radiosensitivity was 80.25,and the specificity was 59.1%.Conclusion miRNA-451 is associated with radiosensitivity in patients with NSCLC and may be a potential therapeutic target.

关 键 词:非小细胞肺癌 放疗敏感性 miRNA-451 

分 类 号:R979.1[医药卫生—药品;医药卫生—药学]

 

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