艽龙胶囊制备中4种主化学成分的转移率研究  

Study on the transfer rate of 4 kinds main components in the preparation of Jiaolong Capsules

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作  者:肖会敏 何悦 雷美娜 常瑛 刘铁明 王四旺 XIAO Huimin;HE Yue;LEI Meina;CHANG Ying;LIU Tieming;WANG Siwang(Institute of Materia Medica,School of Pharmacy,the Air Force Military Medical University,Xi′an 710032,China;Department of Pharmacy,the Northwest Women and Children′s Hospital,Xi′an 710065,China;Xi′an Zhengda Pharmaceutical Limited Company,Xi′an 710043,China)

机构地区:[1]空军军医大学药学院药物研究所,西安710032 [2]西北妇女儿童医院药剂科,西安710065 [3]西安正大制药有限公司,西安710043

出  处:《西北药学杂志》2019年第1期1-5,共5页Northwest Pharmaceutical Journal

基  金:陕西省科技创新组建计划项目(编号:2015SF2-08-01)。

摘  要:目的建立同时测定秦艽药材与艽龙胶囊中的马钱苷酸、6′-O-β-D-葡萄糖基龙胆苦苷、獐芽菜苦苷和龙胆苦苷含量的HPLC法,并探讨其在秦艽药材至艽龙胶囊成药间的转移率。方法采用HPLC法,选取10批秦艽药材,每批对应1批胶囊。结果建立同时检测药材与胶囊中4种成分的HPLC法;10批药材及其对应10批胶囊的马钱苷酸、6′-O-β-D-葡萄糖基龙胆苦苷、獐芽菜苦苷和龙胆苦苷转移率分别为48.90%~86.47%,87.23%~97.88%,21.34%~44.67%和81.47%~96.15%。结论该含量测定方法简便、准确、重复性好,可作为秦艽药材与艽龙胶囊中4种主成分的检测方法;龙胆苦苷为该胶囊主要成分且转移率高,表明该胶囊制备工艺良好,为胶囊的质量控制提供了保障。Objective To establish an HPLC method for determing the contents of gentiopicroside,loganic acid,swertiamarinin and 6′-O-β-D-glucosylgentiopicroside in Gentiana macrophylla Radix and Jiaolong Capsules,and clarify their transfer rate in the preparation.Methods HPLC analysis was adopted,then 10 batches of Gentiana macrophylla Radix were selected each batch of which matched 1 batch of Jiaolong Capsules.Results An HPLC method was established for the determination of the 4 components in medicinal materials and preparations;and the transfer rates of loganic acid,6′-O-β-D-glucosylgentiopicroside,swertiamarin and gentiopicroside in 10 batches of medicinal materials and their corresponding preparations were 48.90%-86.47%,87.23%-97.88%,21.34%-44.67%and 81.47%-96.15%,respectively.Conclusion The method is simple,stable,reliable,and accurate,so it can be used as a quantitative method for Gentiana macrophylla Radix and Jiaolong Capsules.The gentiopicroside is a main active component,and its transfer rates is high in the preparation,which provides a theoretical basis for the preparation of curative effect.

关 键 词:艽龙胶囊 马钱苷酸 6′-O-β-D-葡萄糖基龙胆苦苷 獐芽菜苦苷 龙胆苦苷 HPLC法 

分 类 号:R917[医药卫生—药物分析学;医药卫生—药学]

 

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