黑曲发酵茯苓多糖免疫调节作用研究  

Study on the Immunoregulation of Fermented Poria cocos Polysaccharides by Aspergillus niger

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作  者:李世杰[1] 李勇[1] 曾海英[1] LI Shi-jie;LI Yong;ZENG Haiying(College of Liquor and Food Engineering,Guizhou University,Guiyang 550025,Guizhou,China)

机构地区:[1]贵州大学酿酒与食品工程学院,贵州贵阳550025

出  处:《食品研究与开发》2019年第1期37-41,共5页Food Research and Developent

基  金:贵州省科技计划(黔科合农G字[2015]4003号);贵州省科技计划(黔科合重大专项字(2014)6023);贵州省科技计划(黔科合LH字[2014]7673).

摘  要:研究黑曲发酵茯苓多糖对免疫抑制小鼠的免疫调节作用,通过构建免疫抑制小鼠模型,将小鼠随机分为4组,即空白对照组(CK)、环磷酰胺模型组(cyclophosphamide,CY)及发酵茯苓多糖(fermented Poriacocos polysaccharides,FPCP)高、低剂量组。小鼠以灌胃方式给予不同剂量发酵茯苓多糖,分别测定脏器指数、血清溶血素水平、免疫球蛋白G(immunoglobulin G,IgG)与免疫球蛋白M(immunoglobulin M,IgM)含量及单核-巨噬细胞吞噬率。结果表明,与模型组相比,发酵茯苓多糖各剂量组均能显著提高小鼠脏器指数、溶血素水平、IgG与IgM含量、单核-巨噬细胞吞噬率。发酵茯苓多糖能有效增强环磷酰胺致免疫低下小鼠的免疫调节作用。To study the immunoregulatory effect of Aspergillus niger fermentation polysaccharide on immunosuppressive mice,immunosuppressed mouse model was constructed.The mice were randomly divided into 4 groups:control check(CK),cyclophosphamide model group(CY),high-dose and low-dose groups of fermented Poria cocos polysaccharides(FPCP).The mice were given different doses of fermented polysaccharides by gavage,and the organ index,serum hemolysin level,immunoglobulin G(IgG)and immunoglobulin M(IgM)content,macrophage phagocytosis rate were measured.The results showed that compared with the model group(CY),each dose of FPCP significantly increased the mouse organ index,hemolysin level,IgG and IgM content,and macrophage phagocytosis rate.The polysaccharides fermented by Aspergillus niger can effectively enhance the immunoregulatory effect of immunocompromised mice.

关 键 词:发酵 茯苓多糖 免疫调节 

分 类 号:TS218[轻工技术与工程—粮食、油脂及植物蛋白工程;轻工技术与工程—食品科学与工程]

 

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