酒精性肝病动物模型研究进展  被引量:10

Animal models of alcohol liver diseases

加关注

下载全文

作  者:周恒[1,2] 李俊[1,3] 王华[1,2,3] ZHOU Heng;LI Jun;WANG Hua;College of Pharmacy of Anhui Medical University;Dept of Oncology,the First Affiliated Hospital of Anhui Medical University;Institute for Liver Diseases of Anhui Medical University;

机构地区:[1]安徽医科大学药学院,安徽合肥230032 [2]安徽医科大学第一附属医院肿瘤科,安徽合肥230032 [3]安徽医科大学肝病研究所,安徽合肥230032

出  处:《中国药理学通报》2016年第4期468-472,共5页Chinese Pharmacological Bulletin

基  金:国家自然科学基金优秀青年基金项目(81522009/H0317);新世纪优秀人才支持计划(NoNCET-13-0644);安徽省皖江学者计划资助.

摘  要:长期饮酒是全世界导致慢性肝病的重要原因,可导致肝硬化和肝癌.缺乏能够完全模拟人类酒精性肝病的动物模型限制了酒精性肝病病理机制的研究.因此,建立或者改进酒精性动物模型对于研究酒精性肝病机制,进而提出治疗方案具有重要意义.目前,使用最广泛的酒精性肝损伤模型有急性酒精灌胃模型、Lieber-DeCarli模型、Tsukamoto-French模型和Gaobinge模型等,该文总结并评价了这些酒精性肝病的动物模型,这些动物模型为研究酒精性肝病和开发新的治疗性药物提供了非常有用的研究工具.Chronic alcohol consumption is a leading cause of chronic liver diseases worldwide,resulting in cirrhosis and hepatocellular carcinoma. Almost all heavy drinkers develop fatty liver,but only 20% ~ 40% of them develop more severe forms of alcoholic liver diseases such as alcoholic hepatitis and alcoholic fibrosis,and the underlying mechanisms that contribute to the disease progression remain largely unknown. The animal models which can mimic human alcoholic liver diseases are very necessary tools for better understanding and exploring the therapy strategy of the disease. Currently,the most widely used models for alcoholic liver injury are Lieber-De Carli model,TsukamotoFrench model,Gao-binge model and others. Here we summarize the recent advances in animal models recapitulating different features and etiologies of human alcoholic liver diseases. These animal models will be very useful for the mechanism study of alcoholic liver diseases and further new therapeutic drug screening.

关 键 词:酒精性肝病 动物模型 脂肪肝 肝损伤 炎症 纤维化 

分 类 号:R-05[医药卫生] R322.47[医药卫生—人体解剖和组织胚胎学;医药卫生—基础医学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象